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Hormone buy anastrozole 30 tablets Melbourne receptor-positive breast cancer, currently defined on the basis of the immunohistochemical expression of the estrogen receptor (ER) buy anastrozole 30 tablets Melbourneand of the progesterone receptor (PgR), constitutes about 60% of breast cancers arising in premenopausal women and 80% of those diagnosed after menopause (Clark et al. 1984).
Regarding the question buy anastrozole 30 tablets Melbourne of who needs chemotherapy, the key trial is TAILORx (Trial Assigning Individualized Options for Treatment). In TAILORx, which buy anastrozole 30 tablets Melbourne was originally published in 2018, more than 10,000 women were categorized as being at low, intermediate, or high risk for recurrence based on their score on the Oncotype DX assay: 0 to 10, 11 to 25, buy anastrozole 30 tablets Melbourne or 26 and higher, respectively.
Several trials have since buy anastrozole 30 tablets Melbourne confirmed a benefit of ovarian ablation or suppression in premenopausal women with breast cancer. An overview buy anastrozole 30 tablets Melbourne conducted by the Early Breast Cancer Trialists’ Collaborative Group demonstrated disease-free survival and overall survival benefits among women < 50 years old treated with buy anastrozole 30 tablets Melbourne ovarian ablation or suppression compared to those receiving no adjuvant endocrine therapy.3 However, ovarian treatments fell out of vogue when an oral endocrine therapy (tamoxifen) was approved in the adjuvant setting.